CONTEXT. Patient engagement in research is the practice of involving patients as partners across the research cycle. This practice has quickly become an international standard, with funding bodies actively encouraging it. The increased incentive to engage patients can lead to tokenistic partnerships, it is therefore important to consider the experiences of patient-partners. OBJECTIVE. To synthesize the qualitative literature on the experience of patients as partners in research. DESIGN. Systematic review of the literature with thematic synthesis, guided by the framework developed by Thomas et al. (2008) DATASET. A search strategy was developed to encompass keywords relating to patient-partners in research, their experience, and the qualitative nature of the target studies. 10 databases were searched using the EBSCO-host engine, along with the Scopus engine to include EMBASE. POPULATION STUDIED. The search results were screened for the following inclusion criteria: articles written in English; articles reporting on the experience of patient-partners in research; qualitative studies or mixed-methods studies with a distinct qualitative section. ANALYSIS. Included articles were charted for general information. The CASP qualitative checklist was used for critical appraisal. The “results” section of each article was coded line by line. Codes were aggregated inductively to form descriptive themes and analytical themes. RESULTS. The initial search yielded 10,222 results. After the removal of duplicates, 5534 titles and abstracts were screened, 88 full-text reports were evaluated, and 41 studies were included. Articles reporting on these studies were published between 2005 and 2020. Seven themes emerged from the analysis, ranging from “motivations to engage in research” to “impacts on broader life”. Articles reported varying degrees of perceived impact on research and satisfaction concerning the level of engagement. The importance of power differentials and team dynamics were widely stated. CONCLUSIONS. Findings provide an in-depth view of the experiences of patient-partners in research. Most articles reported a generally positive experience, but challenges and pitfalls of patient engagement were identified. This will serve research teams by highlighting good practices and possible improvements.