CONTEXT: Supporting patients in weight loss is becoming increasingly more important in primary care, as we observe the rise in obesity and obesity-related morbidity and mortality. OBJECTIVE: To determine the effect of various pharmacologic regimens compared to lifestyle interventions alone on weight loss for patients with a BMI >27. STUDY DESIGN and ANALYSIS: Prospective observational study. Data will be pooled and analyzed comparing mean percent body weight change and mean BMI change over 3 and 6 months intervals in each group. SETTING: Saint Anthony North Family Medicine clinic. POPULATION STUDIED: Patients 18 years or older with a BMI >27 who were interested in physician-supported weight loss. INTERVENTION: The experimental treatment groups analyzed were: phentermine, phentermine/topiramate, bupropion, or bupropion/naltrexone. The control group was comprised of patients who elected for lifestyle interventions alone. The pharmacologic therapy selected per patient was not randomized and was determined following an individual discussion between the patient and physician. OUTCOME MEASURES: All patients were followed longitudinally and received individualized weight loss and lifestyle counseling at each visit. Weight loss progress for the study was measured at 3-month and 6-month intervals. RESULTS: The effect of various pharmacologic regimens and lifestyle counseling on weight loss in a primary care setting will be assessed. EXPECTED OUTCOMES: Researchers predict that the greatest weight loss will be seen in treatment groups phentermine alone or phentermine/topiramate.