Context: The National Health Service Institute for Innovation and Improvement Sustainability Model (NHS SM) is recommended by several organisations to implement sustainable healthcare innovations. Although several knowledge syntheses have been conducted about sustainability models in general, none have focussed specifically on the NHS SM to generate a complete and pragmatic summary of the evidence supporting its use. Objective: To explore the depth and breadth of evidence about the NHS Sustainability Model and its use to support sustainable healthcare evidence-based innovation. Study Design: We use Levac’s (2010) six-stage scoping review methodology and the study is conducted and reported using the PRISMA extension for scoping reviews (PRISMA-ScR) Dataset: Eight scientific databases (PubMed, Embase, CINAHL, Web of Science, PsycInfo (Ovid), Academic Search Premier, Wiley Online Library and Science Direct) and four grey literature sources (Google, Google Scholar, DuckDuckGo, Mednar) have been queried. Population studied: Published papers, conference abstracts and posters, conference proceedings, theses, reports and websites that refer to the NHS SM. Exclusion criteria: documents published or created before 2006 (date of the first publication about the NHS sustainability model) OR papers not referring to the NHS SM in the main text of the document OR documents written in languages other than English, Spanish, and French OR documents not about health or social services context. A total of 141 documents extracted from scientific databases have been studied. The grey literature has yet to be screened. Outcome Measures: We expect to (1) map the literature and identify research gaps concerning the NHS SM; (2) describe the contexts in which NHS SM has been used; (3) synthesize NHS SM’s strengths and weaknesses; (4) inventory the barriers and facilitators that affect the model’s use. Results: This study presents a systematic synthesis of the evidence supporting the use of the NHS SM for decision makers planning the implementation of healthcare innovations and identify knowledge gaps for future research concerning the NHS SM.