Context: COVID-19 has led to significant challenges in clinic workflows. Prior to COVID-19, our group had created and established a standardized workflow to minimize delays in medication refills. Objective: To enhance and expand a multidisciplinary medication refill protocol and evaluate the effects of the COVID-19 pandemic on its efficiency. Study Design: Retrospective comparative study. Setting: Two residency clinics in Milwaukee, Wisconsin. Population studied: All patients seen within two clinics, pre-pandemic (06/01/2019-03/31/2020) vs. pandemic (04/01/2020-12/31/2020). Outcome measures: Time to completion of medication refill and variance in times to completion. Methods: Expanded medication refill protocol that identifies common low-risk medications to be refilled by nurses to reduce refill delays. Time between opening and closure of an EMR refill request encounter was measured and compared between time periods and two clinics. Time for medication refill completion was also compared between provider type. Mood’s median test was used to compare the median time for a medication refill completion. Levene’s test was used to test for equal variances surrounding the median of each group. Results: Cohorts included both clinics pre-pandemic (n=14623), both clinics during the pandemic (n=14251), Clinic 1 (n=18587), and Clinic 2 (n=10287); with a combined total of 28874 refill encounters. We found a statistically significant reduction in median time to refill, and variance between the two time periods, 557 minutes in the pre-pandemic phase to 419 minutes during the pandemic (P<0.001). Overall, we also found significant differences in median time to refill and variance between Clinic 1 (561 minutes) and Clinic 2 (325 minutes) with a P<0.001. When comparing times between subgroups of ordering users in both clinics combined (residents [n=5928], faculty [n=6656], and clinic nurses [n=16290]), we found statistically significant differences in time to refill and variance between all three, with residents’ median time 694 minutes, faculty 559 minutes, and nurses 426 minutes (P=0.02). Conclusion: This project reinforces the importance of a standardized multidisciplinary medication refill protocol to increase consistency and decrease medication refill time. Additionally, it has shown success when expanded to a sister academic family medicine clinic during a system-wide stressor such as the COVID-19 pandemic.