Context: Black men are disproportionately impacted by prostate cancer. Current guidelines recommend that all men make informed decisions about whether to be screened for prostate cancer. Primary care providers are uniquely positioned to facilitate these conversations. Little is known about the barriers and facilitators of informed decision making about prostate cancer screening in Black men. Objective: To characterize the factors impacting informed decision making among Black men regarding prostate cancer screening in the context of significant racial disparities. Study Design: We conducted qualitative focus groups. Template analysis was used to evaluate themes. Setting or Dataset: A convenience sample of participants was recruited from an academic family medicine practice. Population studied: 21 self-identified Black men aged 55-69 who were patients of the academic family medicine practice. Men with a history of prostate cancer, men undergoing treatment for any cancer, men with terminal illness, or men unable to give informed consent were excluded. Outcome Measures: To identify barriers and facilitators to informed decision making about prostate cancer screening in Black men Results: Informed decision making was impacted by external factors, intrinsic factors, and personal beliefs about prostate cancer screening. Family, friends, and clinicians played a paramount role in shaping attitudes about prostate cancer screening. Distrust of the medical community impaired informed decision making, and lack of clinician communication about prostate cancer screening further engendered mistrust. Participants felt they lacked adequate knowledge to make an informed decision about prostate cancer screening. Identified areas to promote informed decision making included education on racial disparities, education that screening is a personal choice, and differentiating prostate cancer screening from colon cancer screening Conclusions: Black men may lack the prerequisite information to make informed decisions about prostate cancer screening, which is notable in light of known prostate cancer racial disparities. Clinicians can play an important role in facilitating informed decision making through fostering discussions about the benefits and risks of prostate cancer screening and educating Black men about racial disparities.